Chines Journal of Vector Biology and Control ›› 2010, Vol. 21 ›› Issue (3): 235-237.

• Original reports • Previous Articles     Next Articles

Prevalence of Hantavirus infections in humans and animals in Wenzhou city 

LIN Xian-Dan1, GUO Wen-Ping2,3, WANG Wen2,3, ZHANG Xiao-He1, CHEN Yi1, XIE Hai-Bin4, ZHENG Gang4, LIAO Xiao-Wei5, CHEN Sheng-Ze6, HU Yong-Wei6, ZHENG Xiao-Chun1, LI Wan-Cang1, NI Qing-Xiang1, ZHANG Yong-Zhen2   

  1. 1 Wenzhou Center for Disease Control and Prevention, Wenzhou 325001, Zhejiang Province, China; 2 State Key Laboratory for Infectious Disease Control and Prevention, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; 3 College of Life Science, Shihezi University;  4 Lucheng  District  Center  for  Disease  Control  and  Prevention;  5 Ruian  Center  for  Disease Control and Prevention; 6 Yongjia County Center for Disease Control and Prevention
  • Received:2009-12-21 Online:2010-06-20 Published:2010-06-20
  • Contact: ZHANG Yong?zhen, Email: yongzhenzhang@sohu.com

汉坦病毒在温州市人与动物间的流行情况

林献丹1,郭文平2,3,王文2,3,张孝和1,陈祎1,谢海斌4,郑刚4,廖晓伟5,陈胜则6,胡永卫6,郑晓春1,李万仓1,倪庆翔1,张永振2   

  1. 1 温州市疾病预防控制中心免疫预防科(浙江 温州 325001); 2 中国疾病预防控制中心传染病预防控制所,传染病预防控制国家重点实验室(北京 102206); 3 新疆石河子大学生命科学学院; 4 鹿城区疾病预防控制中心; 5 瑞安市疾病预防控制中心; 6 永嘉县疾病预防控制中心
  • 通讯作者: 张永振,Email: yongzhenzhang@sohu.com
  • 作者简介:林献丹(1974-),女,主管医师,从事传染病预防控制工作。

Abstract:

Objective The prevalence of hemorrhagic fever with renal syndrome (HFRS) was monitored and analyzed to reveal the epidemiologic characteristics of HFRS in Wenzhou, in order to provide the basis for development of the control and prevention strategies for HFRS. Methods A descriptive epidemiologic approach was employed to analyze the prevalence of HFRS in humans in Wenzhou from 1981 to 2008. Cage traps were used to capture small mammals for investigation of the species composition of animal hosts. The indirect immunofluorescence assay was used to detect the Hantavirus (HV) antigens in animal lungs, which were then genotyped by PCR. Results A total of 383 cases were reported from 1981 to 2008 with an average incidence rate of 0.20/105. There were 13 death cases, with a fatality rate of 3.39%. The cases were distributed in all the ten counties (cities, districts) of the city, particularly in Ruian, where the number of cases accounted for 53.78%. Significant seasonality was observed as the prevalence peaked in winter (from November to January of the following year) when the number of cases accounted for 41.25%. Most cases were 20 to 50 years, accounting for 74.76% of the total number. In regard to the monitoring of host animals, the outdoor capture rate was 7.16% and the indoor one was 7.88%. The dominant species outdoors was Niviventer confucianus, followed by Rattus losea; the dominant species indoors was R. norvegicus, followed by R. tanezumi. A total of 422 rat lungs were investigated, resulting in nine HV antigen?positive specimens with the positive rate of 2.13%. The sole genotype of the extract of viral RNA in the HV antigen?positive rat lung tissues was SEOV. Conclusion Comprehensive prevention and control measures, including strengthened monitoring, deratization and vaccination shall be implemented to effectively prevent HFRS epidemic.

Key words: Hemorrhagic fever with renal syndrome, Incidence rate, Hantavirus, Genotyping

摘要:

目的 通过对肾综合征出血热(HFRS)监测分析,掌握温州市HFRS的流行规律,为制定HFRS防制措施提供依据。方法 采用描述流行病学方法对温州市1981-2008年HFRS人间疫情进行分析;用鼠笼捕捉小动物调查宿主动物种群构成,采用间接免疫荧光法检测小动物肺中的汉坦病毒(HV)抗原,用PCR进行基因分型。结果 1981-2008年全市共发病383例,平均发病率为0.20/10万,死亡13例,病死率为3.39%。全市10个县(市、区)均有发病,尤以瑞安市发病最多,占总病例数的53.78%。发病呈明显的季节性,冬季(11月至翌年1月)为流行高峰,占总病例数的41.25%。病例以20~50岁人群为主,占发病总数的74.76%。宿主动物监测发现野外捕获率7.16%,室内捕获率7.88%。野外以北社鼠为优势鼠种,其次为黄毛鼠;室内以褐家鼠为优势鼠种,其次为黄胸鼠。检测422份小动物肺,HV抗原阳性9份,阳性率为2.13%。提取HV抗原阳性鼠肺组织中的病毒RNA,基因分型全部为汉城病毒(SEOV)。结论 调查结果提示应采取加强监测、防鼠灭鼠、疫苗接种等综合防控措施,以有效预防HFRS的流行。

关键词: 肾综合征出血热, 发病率, 汉坦病毒, 基因分型

CLC Number: