Application and prospect of insecticides targeting nicotinic acetylcholine receptors in control of sanitary pests

doi:10.11853/j.issn.1003.8280.2020.06.026

Abstract

Abstract: Insecticides targeting nicotinic acetylcholine receptors are not only used in the control of agricultural pests, but also have good killing effects on sanitary pests. With increasing attention to high toxicity to bees, the development of traditional insecticides such as imidacloprid and thiamethoxam has entered a bottleneck period. Changing the way of use may help these insecticides get out of the dilemma. This paper reviews the development history, current dilemma, application status in the sanitary field, and new products of insecticides acting at nicotinic acetylcholine receptors, and discuss the prospect of such insecticides in sanitary pest control.

Key words: Insecticides targeting nicotinic acetylcholine receptors, Sanitary pest, Application status, Prospect

摘要： 烟碱乙酰胆碱受体作用剂不仅应用于农业害虫防治，还对卫生害虫有着优良的杀灭效果。随着“高蜂毒”问题逐渐被重视，吡虫啉、噻虫嗪等传统杀虫剂的发展陷入瓶颈期，而改变使用方式是传统杀虫剂走出困境的出路之一。该文论述了烟碱乙酰胆碱受体作用剂的发展历史、目前困境、卫生领域的应用现况和新产品的开发情况，阐明了该类杀虫剂在卫生害虫防治方面的应用前景。

关键词: 烟碱乙酰胆碱受体作用剂, 卫生害虫, 防治现况, 前景展望

CLC Number:

R382.3

WANG Dong, ZHANG Xiao, LI Chuan-xia, XIN Zheng. Application and prospect of insecticides targeting nicotinic acetylcholine receptors in control of sanitary pests[J]. Chines Journal of Vector Biology and Control, 2020, 31(6): 744-748.

王东, 张晓, 李传霞, 辛正. 烟碱乙酰胆碱受体作用剂在卫生害虫防治领域的应用及展望[J]. 中国媒介生物学及控制杂志, 2020, 31(6): 744-748.

References

[1] 严明,柏亚罗. 双酰胺类等五大类热点农药的市场概况及产品研发[J]. 现代农药,2019,18(1):7-15. DOI:10.3969/j.issn.1671-5284.2019.01.002. Yan M,Bai YL. Market overview and product R&D on five hot pesticide sectors including diamide class[J]. Mod Agrochem,2019,18(1):7-15. DOI:10.3969/j.issn.1671-5284.2019.01.002.
[2] 段丽芳. 欧盟通过决议禁止新烟碱类农药噻虫胺、吡虫啉及噻虫嗪的户外使用[J]. 农药科学与管理,2018,39(5):29. Duan LF. EU decision to ban outdoor use of neonicotinoid insecticides thiamidosamine,imidacloprid and thiamazide[J]. Pestic Sci Admini,2018,39(5):29.
[3] 吴艳艳,周婷,贾慧茹. 有关美国俄勒冈州新烟碱类杀虫剂的禁令[J]. 中国蜂业,2014,65(6):61. DOI:10.3969/j.issn. 0412-4367.2014.06.035. Wu YY,Zhou T,Jia HR. Ban on neonicotinoid insecticides in Oregon,USA[J]. Apicult China,2014,65(6):61. DOI:10.3969/j.issn.0412-4367.2014.06.035.
[4] 余露. 加拿大将在2~3年内淘汰噻虫胺、吡虫啉、噻虫嗪某些用途[J]. 农药市场信息,2019(9):45. Yu L. Canada will phase out certain uses of thiamethylamine,imidacloprid and thiamethazine within 2-3 years[J]. Pestic Market News,2019(9):45.
[5] Iwasa T,Motoyama N,Ambrose JT,et al. Mechanism for the differential toxicity of neonicotinoid insecticides in the honey bee,Apis mellifera[J]. Crop Prot,2004,23(5):371-378. DOI:10.1016/j.cropro.2003.08.018.
[6] Laurino D,Manino A,Patetta A,et al. Acute oral toxicity of neonicotinoids on different honey bee strains[J]. J Zool,2010,93:99-102.
[7] Grillone G,Laurino D,Manino A,et al. Toxicity of thiametoxam on in vitro reared honey bee brood[J]. Apidologie,2017,48(5):635-643. DOI:10.1007/s13592-017-0506-6.
[8] Whitehorn PR,O'Connor S,Wackers FL,et al. Neonicotinoid pesticide reduces bumble bee colony growth and queen production[J]. Science,2012,336(6079):351-352. DOI:10.1126/science.1215025.
[9] Tan K,Chen WW,Dong SH,et al. A neonicotinoid impairs olfactory learning in Asian honey bees (Apis cerana) exposed as larvae or as adults[J]. Sci Rep,2015,5:10989. DOI:10.1038/srep10989.
[10] 李梦,李志国,和静芳,等. 新烟碱类杀虫剂对蜜蜂行为与生理影响的研究进展[J]. 福建农林大学学报:自然科学版,2016,45(5):490-495. DOI:10.13323/j.cnki.j.fafu(nat.sci.). 2016.05.002. Li M,Li ZG,He JF,et al. Advances in effect of neonicotinoid insecticides on behavior and physiology of honey bees[J]. J Fujian Agri For Univ:Nat Sci Ed,2016,45(5):490-495. DOI:10.13323/j.cnki.j.fafu(nat.sci.).2016.05.002.
[11] 王宇飞,施腾飞,齐磊,等. 亚致死浓度噻虫嗪对意大利蜜蜂进食量的影响[J]. 中国蜂业,2017,68(2):22-23. DOI:10.3969/j.issn.0412-4367.2017.02.003. Wang YF,Shi TF,Qi L,et al. Effects of the sublethal thiamethoxam on food intake of Apis mellifera ligustica[J]. Apicul China,2017,68(2):22-23. DOI:10.3969/j.issn.0412-4367.2017.02.003.
[12] 杨光. 新烟碱类杀虫剂或致蜜蜂极易受到致命螨虫侵害[J]. 农药市场信息,2019(10):49. Yang G. Neonicotinoid insecticides can make bees vulnerable to deadly mites[J]. Pestic Market News,2019(10):49.
[13] 吴若函,丁悦,严海娟,等. 新烟碱类杀虫剂对几种环境生物的安全性评价[J]. 江苏农业科学,2016,44(1):295-297. DOI:10.15889/j.issn.1002-1302.2016.01.087. Wu RH,Ding Y,Yan HJ,et al. Safety evaluation of neonicotinoid insecticides to several environmental organisms[J]. Jiangsu Agric Sci,2016,44(1):295-297. DOI:10.15889/j.issn.1002-1302.2016.01.087.
[14] 吴程琛. 新型新烟碱类农药对环境模式生物毒性效应的研究[D]. 杭州:浙江大学,2016. Wu CC. The behaviors and toxic effects of neonicotinoid pesticides in model organisms[D]. Hangzhou:Zhejiang University,2016.
[15] 尹力. 新烟碱类杀虫剂对3种水生生物的安全性评价[D]. 南京:南京农业大学,2017. Yin L. Safety evaluation of three aquatic organisms by neonicotinoid insecticides[D]. Nanjing:Nanjing Agricultural University,2017.
[16] Mitchell EAD,Mulhauser B,Mulot M,et al. A worldwide survey of neonicotinoids in honey[J]. Science,2017,358(6359):109-111. DOI:10.1126/science.aan3684.
[17] 谭颖,张琪,赵成,等. 蔬菜水果中的新烟碱类农药残留量与人群摄食暴露健康风险评价[J]. 生态毒理学报,2016,11(6):67-81. DOI:10.7524/AJE.1673-5897.20160421001. Tan Y,Zhang Q,Zhao C,et al. Residues of neonicotinoid pesticides in vegetables and fruit and health risk assessment of human exposure via food intake[J]. Asian J Ecotoxicol,2016,11(6):67-81. DOI:10.7524/AJE.1673-5897.20160421001.
[18] 宋超. 新烟碱类杀虫剂在烟叶中的残留降解及环境行为研究[D]. 北京:中国农业科学院,2015. DOI:10.7666/d.Y2788051. Song C. Residue degradation in tobacco leaves and environmental behavior of neonicotinoid insecticide[D]. Beijing:Chinese Academy of Agricultural Sciences,2015. DOI:10.7666/d.Y2788051.
[19] 李义强,曹爱华,任广伟,等. 氯噻啉对烟蚜的防治效果和烟叶中农药残留规律研究[J]. 中国烟草学报,2010,16(4):63-66. DOI:10.3969/j.issn.1004-5708.2010.04.013. Li YQ,Cao AH,Ren GW,et al. The control effect of imidaclothiz against Myzus persicae and its residue in tobacco leaf[J]. Acta Tabaca Sin,2010,16(4):63-66. DOI:10.3969/j.issn.1004-5708.2010.04.013.
[20] 冯磊,张兰,张燕宁,等. 三种新烟碱类农药对蚯蚓体重及溶酶体膜的影响[J]. 植物保护,2015,41(3):35-39. DOI:10.3969/j.issn.0529-1542.2015.03.007. Feng L,Zhang L,Zhang YN,et al. Effects of three neonicotinoids on the weight and neutral red retention time of earthworm (Eisenia fetida)[J]. Plant Prot,2015,41(3):35-39. DOI:10.3969/j.issn.0529-1542.2015.03.007.
[21] Zhang YN,Zhang L,Feng L,et al. Oxidative stress of imidaclothiz on earthworm Eisenia fetida[J]. Comp Biochem Physiol C Toxicol Pharmacol,2017,191:1-6. DOI:10.1016/j.cbpc.2016.09.001.
[22] 戴宝江. 新颖杀虫剂:氯噻啉[J]. 世界农药,2005,27(6):46-47. Dai BJ. Novel insecticide:imidaclothiz[J]. World Pestic,2005,27(6):46-47.
[23] 江苏克胜集团股份有限公司. 又一自主创新农药获农业部登记[J]. 农化市场十日讯,2017(18):34. Jiangsu Kesheng Group Co.,Ltd. Another independent and innovative pesticide was registered with the Ministry of Agriculture[J]. J Agric Mark,2017(18):34.
[24] 孙海燕,陈伟国,戴建忠. 哌虫啶对家蚕的急性毒性和残毒期测定[J]. 江苏蚕业,2012,34(1):22-23. Sun HY,Chen WG,Dai JZ. Determination of acute toxicity and residual toxicity of paichongding to silkworm[J]. Jiangsu Sericul,2012,34(1):22-23.
[25] 陈伟国,孙海燕,戴建忠. 新烟碱类杀虫剂环氧虫啶对家蚕的毒性评价[J]. 江苏蚕业,2014,36(1):12-15. DOI:10.3969/j.issn.1003-9848.2014.01.004. Chen WG,Sun HY,Dai JZ. Toxicity evaluation of a neonicotinoid insecticide cycloxaprid on silkworm[J]. Jiangsu Sericul,2014,36(1):12-15. DOI:10.3969/j.issn.1003-9848.2014.01.004.
[26] Qi SZ,Wang DH,Zhu LZ,et al. Neonicotinoid insecticides imidacloprid,guadipyr,and cycloxaprid induce acute oxidative stress in Daphnia magna[J]. Ecotoxicol Environ Saf,2018,148:352-358. DOI:10.1016/j.ecoenv.2017.10.042.
[27] Zhang JH,Zhang S,Yang YX,et al. New insight into foregut functions of xenobiotic detoxification in the cockroach Periplaneta americana[J]. Insect Sci,2017,25(6):978-990. DOI:10.1111/1744-7917.12486.
[28] 李黎,巨修练. 绿色农药环氧啉的开发及应用[J]. 湖北植保,2009(5):55-56. DOI:10.3969/j.issn.1005-6114.2009.05.030. Li L,Ju XL. Development and application of green pesticide,cycolxylidin[J]. Hubei Plant Prot,2009(5):55-56. DOI:10.3969/j.issn.1005-6114.2009.05.030.
[29] 巨修练,胡福临,王均震,等. 环氧虫啉的晶体结构及其杀虫活性[J]. 武汉工程大学学报,2013,35(12):17-21. DOI:10.3969/j.issn.1674-2869.2013.12.004. Ju XL,Hu FL,Wang JZ,et al. Crystal structure and insecticidal activity of huanyangchonglin[J]. J Wuhan Inst Technol,2013,35(12):17-21. DOI:10.3969/j.issn.1674-2869.2013.12.004.
[30] 韩金涛,苏旺苍. 新型硝基缩氨基胍类杀虫剂:戊吡虫胍[J]. 山东农药信息,2013(12):19-20. Han JT,Su WC. The novel nitrohydrazine:carboximidamides insecticide:guadipyr[J]. Shandong Pestic News,2013(12):19-20.
[31] Wang K,Mu XY,Qi SZ,et al. Toxicity of a neonicotinoid insecticide,guadipyr,in earthworm (Eisenia fetida)[J]. Ecotoxicol Environ Saf,2015,114:17-22. DOI:10.1016/j.ecoenv.2014.12.037.
[32] Qi SZ,Wang C,Chen XF,et al. Toxicity assessments with Daphnia magna of Guadipyr,a new neonicotinoid insecticide and studies of its effect on acetylcholinesterase (AChE),glutathione S-transferase (GST),catalase (CAT) and chitobiase activities[J]. Ecotoxicol Environ Saf,2013,98:339-344. DOI:10.1016/j.ecoenv.2013.09.013.
[33] 李冬植,王凯,徐莉,等. 戊吡虫胍对几种非靶标生物的急性毒性[J]. 生态毒理学报,2016,11(3):331-337. DOI:10.7524/AJE.1673-5897.20150921001. Li DZ,Wang K,Xu L,et al. Acute toxicity of guadipyr to non-target organisms[J]. Asian J Ecotoxicol,2016,11(3):331-337. DOI:10.7524/AJE.1673-5897.20150921001.
[34] Cutler P,Slater R,Edmunds AJF,et al. Investigating the mode of action of sulfoxaflor:a fourth-generation neonicotinoid[J]. Pest Manag Sci,2013,69(5):607-619. DOI:10.1002/ps.3413.
[35] Brar GS,Martini X,Stelinski LL. Lethal and sub-lethal effects of a novel sulfoximine insecticide,sulfoxaflor,against Asian citrus psyllid and its primary parasitoid under laboratory and field conditions[J]. Int J Pest Manage,2017,63(4):299-308. DOI:10.1080/09670874.2016.1258501.
[36] 林仁魁,邹华娇,吴德飞. 氟啶虫胺腈对褐飞虱的田间防治效果[J]. 农药,2012,51(8):619-620. DOI:10.3969/j.issn.1006-0413.2012.08.024. Lin RK,Zou HJ,Wu DF. Field efficacy of sulfoxaflor 240 g/L SC against Nilaparvata lugens (Stål)[J]. Agrochemicals,2012,51(8):619-620. DOI:10.3969/j.issn.1006-0413.2012.08.024.
[37] 肖春霞,张佩文,谭煜婷,等. 氟啶虫胺腈对红火蚁毒杀活性及活动能力的影响[J]. 贵州农业科学,2018,46(4):48-51. DOI:10.3969/j.issn.1001-3601.2018.04.012. Xiao CX,Zhang PW,Tan YT,et al. Effects of sulfoxaflor on death and activity of Solenopsis invicta[J]. Guizhou Agric Sci,2018,46(4):48-51. DOI:10.3969/j.issn.1001-3601.2018.04.012.
[38] Pan FX,Lu YY,Wang L. Toxicity and sublethal effects of sulfoxaflor on the red imported fire ant,Solenopsis invicta[J]. Ecotoxicol Environ Saf,2017,139:377-383. DOI:10.1016/j.ecoenv.2017.02.014.
[39] 杨一平,陈伟国,孙海燕,等. 50%氟啶虫胺腈水分散粒剂对家蚕的毒性评价[J]. 蚕桑通报,2018,49(4):20-23. DOI:10.3969/j.issn.0258-4069.2018.04.004. Yang YP,Chen WG,Sun HY,et al. Toxicity evaluation of 50% sulfoxaflor water dispersible granules to silkworm Bombyx mori[J]. Bull Sericult,2018,49(4):20-23. DOI:10.3969/j.issn.0258-4069.2018.04.004.
[40] 周浩,邵莒南,翟一凡,等. 氟啶虫胺腈、乙基多杀菌素及其混剂对地熊蜂的毒性及风险评估[J]. 昆虫学报,2017,60(7):809-816. DOI:10.16380/j.kcxb.2017.07.009. Zhou H,Shao JN,Zhai YF,et al. Toxicity and risk assessment of sulfoxaflor,spinetoram and their mixture to Bombus terrestris (Hymenoptera:Apidae)[J]. Acta Entomol Sin,2017,60(7):809-816. DOI:10.16380/j.kcxb.2017.07.009.
[41] Smith HA,Giurcanu MC. Residual effects of new insecticides on egg and nymph densities of Bemisia tabaci (Hemiptera:Aleyrodidae)[J]. Fla Entomol,2013,96(2):504-511. DOI:10.1653/024.096.0216.
[42] Chen XD,Seo M,Stelinski LL. Behavioral and hormetic effects of the butenolide insecticide,flupyradifurone,on Asian citrus psyllid,Diaphorina citri[J]. Crop Prot,2017,98:102-107. DOI:10.1016/j.cropro.2017.03.017.
[43] 王欢欢,张春姣,刘梦铭,等. 氟啶虫胺腈等11种杀虫剂对瓜蚜的毒力及协同增效作用[J]. 农药学学报,2019,21(2):181-186. DOI:10.16801/j.issn.1008-7303.2019.0024. Wang HH,Zhang CJ,Liu MM,et al. Toxicities and synergy effects of sulfoxaflor and other ten insecticides against Aphis gossypii Glover[J]. Chin J Pestic Sci,2019,21(2):181-186. DOI:10.16801/j.issn.1008-7303.2019.0024.
[44] Campbell JW,Cabrera AR,Stanley-Stahr C,et al. An evaluation of the honey bee (Hymenoptera:Apidae) safety profile of a new systemic insecticide,flupyradifurone,under field conditions in Florida[J]. J Econ Entomol,2016,109(5):1967-1972. DOI:10.1093/jee/tow186.
[45] Hesselbach H,Scheiner R. Effects of the novel pesticide flupyradifurone (Sivanto) on honeybee taste and cognition[J]. Sci Rep,2018,8:4954. DOI:10.1038/s41598-018-23200-0.
[46] Tan K,Wang C,Dong SH,et al. The pesticide flupyradifurone impairs olfactory learning in Asian honey bees (Apis cerana) exposed as larvae or as adults[J]. Sci Rep,2017,7(1):17772. DOI:10.1038/s41598-017-18060-z.
[47] 王超. 新型杀虫剂氟吡呋喃酮对东方蜜蜂行为能力的影响研究[D]. 昆明:云南农业大学,2016. Wang C. Effect of flupyradifurone on behaviour ability of Apiscerana[D]. Kunming:Yunnan Agricultural University,2016.
[48] Cordova D,Benner EA,Schroeder ME,et al. Mode of action of triflumezopyrim:a novel mesoionic insecticide which inhibits the nicotinic acetylcholine receptor[J]. Insect Biochem Molec Biol,2016,74:32-41. DOI:10.1016/j.ibmb.2016.04.008.
[49] 陈时健,薛金龙. 19%氯虫·三氟苯嘧啶悬浮剂防治稻飞虱、稻纵卷叶螟田间效果试验简报[J]. 上海农业科技,2017(4):129,131. DOI:10.3969/j.issn.1001-0106.2017.04.073. Chen SJ,Xue JL. Field effects of triflumezopyrim suspension on rice planthopper and rice leaf roller[J]. Shanghai Agr Sci Technol,2017(4):129,131. DOI:10.3969/j.issn.1001-0106.2017.04.073.
[50] 唐涛,马明勇,符伟,等. 三氟苯嘧啶·溴氰虫酰胺对水稻稻飞虱及螟虫的田间防治效果评价[J]. 植物保护,2019,45(3):215-221. DOI:10.16688/j.zwbh.2018247. Tang T,Ma MY,Fu W,et al. Evaluation of control efficacy of triflumezopyrim plus cyantraniliprole against rice planthoppers and stem borers under field conditions[J]. Plant Prot,2019,45(3):215-221. DOI:10.16688/j.zwbh.2018247.
[51] Zhu J,Li Y,Jiang H,et al. Selective toxicity of the mesoionic insecticide,triflumezopyrim,to rice planthoppers and beneficial arthropods[J]. Ecotoxicology,2018,27(4):411-419. DOI:10.1007/s10646-018-1904-x.
[52] 王学军,谭海连,宋书琴. 灭蜚蠊毒饵控制德国小蠊密度的应用研究[J]. 中国媒介生物学及控制杂志,2008,19(4):298-300. DOI:10.3969/j.issn.1003-4692.2008.04.007. Wang XJ,Tan HL,Song SQ. An application study on the controlling the density of Blattella germanica by several cockroach poisonous baits[J]. Chin J Vector Biol Control,2008,19(4):298-300. DOI:10.3969/j.issn.1003-4692.2008.04.007.
[53] 金玉华,张经常,闫建平,等. 新疆北屯地区蚊虫种群动态变化及综合防控[J]. 中国媒介生物学及控制杂志,2014,25(4):347-349. DOI:10.11853/j.issn.1003.4692.2014.04.017. Jin YH,Zhang JC,Yan JP,et al. Study on population dynamics and integrated control of mosquitoes in Beitun of Xinjiang,China[J]. Chin J Vector Biol Control,2014,25(4):347-349. DOI:10.11853/j.issn.1003.4692.2014.04.017.
[54] 辛正,王永明,刘慧媛,等. 吡虫啉杀蚁饵剂杀灭小黄家蚁效果及试验方法研究[J]. 中国媒介生物学及控制杂志,2010,21(5):443-444. Xin Z,Wang YM,Liu HY,et al. Toxicity of imidacioprid baits against Monomorrium pharaonis and test methods[J]. Chin J Vector Biol Control,2010,21(5):443-444.
[55] 史慧勤,陈珞艺,韩华,等. 呋虫胺与顺式氯氰菊酯混配对抗性家蝇的控制效果观察[J]. 中华卫生杀虫药械,2016,22(1):19-21,25. DOI:10.19821/j.1671-2781.2016.01.006. Shi HQ,Chen LY,Han H,et al. Efficacy of the mixture of dinotefuran and alpha-cypermethrin against resistant Musca domestica[J]. Chin J Hyg Insect Equip,2016,22(1):19-21,25. DOI:10.19821/j.1671-2781.2016.01.006.