Abstract:

To further study the structure and nature of the foci of plague in Hebei province, this article summarizes the biological characteristics of Yersinia pestis isolates in the regions by analyzing the large amounts of data collected. By introducing the biochemical characteristics, nutritional needs, plasmid characteristics, virulence factors, virulence and toxins and other aspects, the study has concluded that Y. pestis isolated in Hebei province belongs to Group B of the Ordos Plateau, of which the nutritional needs are characterized by glycine semi-dependence and tryptophan dependence. These strains contain 4 kinds of plasmids, of which 13×106 plasmid is specifically carried by Meriones unguiculatus in the Inner Mongolian. Some strains lack the 45×106 plasmid, though all of isolates were F1 antigen and streptozotocin (PstⅠ)-positive. However, only a certain portion of the strains were positive for pigmentation (Pgm) and VW antigen, indicating genetic instability and moderate toxicity.

Key words: Yersinia pestis, Biological characteristic, Virulence factor

摘要：

为进一步研究河北省鼠疫疫源地的结构和性质，通过查阅大量资料，对该疫源地分离的鼠疫菌株的生物学特征做了总结，分别从生化特征、营养需求、质粒特征、毒力因子、毒力和毒素几方面进行介绍，发现河北省分离的鼠疫菌属于B群鄂尔多斯高原型，营养需求表现为对甘氨酸的半依赖和对色氨酸的营养依赖，含有4种质粒，其中13×106质粒是内蒙古长爪沙鼠疫源地所特有，有的菌株缺失45×106质粒，全部菌株表现为F1抗原和鼠疫菌素(PstⅠ)阳性，而鼠疫菌色素沉着(Pgm)和VW抗原阳性仅占一定比例，表现为遗传的不稳定性，中等毒力。

关键词: 鼠疫菌, 生物学特征, 毒力因子