Chines Journal of Vector Biology and Control ›› 2010, Vol. 21 ›› Issue (6): 627-630.

• Original reports • Previous Articles     Next Articles

Advances in research on malaria transmission blocking vaccines

ZHANG Ben-guang, LIU Li-juan, GONG Mao-qing   

  1. Shandong Institute of Parasitic Diseases, Jining 272033, Shandong Province, China
  • Received:2010-05-31 Online:2010-12-20 Published:2010-12-20
  • Supported by:

    Supported by the Science and Technology Development Plan Project of the Health Department of Shandong Province(No. 2007HZ095)

疟疾传播阻断疫苗的研究进展

张本光, 刘丽娟, 公茂庆   

  1. 山东省寄生虫病防治研究所流行病学部(济宁 272033)
  • 通讯作者: 公茂庆, Email: maoqingg@yahoo.com
  • 作者简介:张本光(1978-),男,硕士,从事流行病学研究。Email: zzgg_happy@163.com
  • 基金资助:

    山东省医药卫生科技发展计划项目(2007HZ095)

Abstract:

This paper summarizes the common candidate antigens in transmission blocking vaccines (TBVs) and discusses the status quo of research on antigen vaccines before and after fertilization of gametes, as well as the relevant antigen vaccines in the body of mosquitoes. The hotspots in TBVs such as the study of reactionogenicity of candidate antigens and practical effects of adjuvants and their prospects are also reviewed to provide the basis for further research on malaria transmission blocking vaccines.

Key words: Malaria, Transmission blocking vaccines, Candidate antigens

摘要:

从疟疾传播阻断疫苗常见候选抗原入手,分别讨论了配子受精前的靶抗原疫苗、配子受精后的靶抗原疫苗及蚊体内的相关抗原疫苗的研究现状,并对传播阻断疫苗目前存在的热点问题,如抗原的反应原性、佐剂的应用效果等研究进展及发展前景进行综述,为进一步研究疟疾传播阻断疫苗提供参考。

关键词: 疟疾, 传播阻断疫苗, 候选抗原

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