ISSN 1003-8280 CN 10-1522/R 中国疾病预防控制中心 主办
Chines Journal of Vector Biology and Control
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Zhang Jun*; Tong Zheng; Zhou Lian-di; et al
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张军1; 童政2; 周联娣1; 赵守军1; 叶克龙1; 徐志一1
Abstract: Obective: The purpose of this report was to observe the serofogic and preventive effect of TyPe Ⅰinactivated vaccines against HFRS (prepared from tissue culture of Mongoian gerbils kidney)after rein forcement.Methods: Indirect immunofluorescent antibody methed and Enzyme-linked Immunosorbent Assay indirect sandwich method were used in testing IgG antibody in sera.Microcytopathic effect neutralization test was used in the detection of neutralizing antithey in sera.Results: Before reinforcement, the Positive rate of antithey in sera was 18.3%, and that of neutralization antithey was 0%.2 weeks after reinforcement, the POsitive rate of antibody in sera was 90.1%, and that of nentralization antibody was 75%.1 year after reinforcernent, there was no patient found in the inoculation group, and there were 5 patients found in the control group.
摘要: 目的:观察HFRS沙鼠肾灭活疫苗(Ⅰ型)加强免疫后的血清学效果及防病效果。方法:采用间接免疫荧光试验和双夹心ELISA法,检测血清中的IgG抗体;以微量细胞病变中和试验,检测血清中的中和抗体。结果:加强免疫前,血清抗体阳性率仅为18.3%,中和抗体阳性率为0%;加强免疫后2周,抗体阳性率升至90.1%,中和抗体阳性率达75%。加强免疫后1年内,接种组无1例病人发生,而未接种者发病5例。
关键词: 肾综合征出血热, 灭活疫苗, 加强免疫, 现场实验
Zhang Jun*; Tong Zheng; Zhou Lian-di; et al. Study on Antibody Reaction and Epidemiological Effect after Reinforcement of Type ⅠInactivatcd Vaccines against HFRS[J]. Chines Journal of Vector Biology and Control.
张军1; 童政2; 周联娣1; 赵守军1; 叶克龙1; 徐志一1. 肾综合征出血热Ⅰ型灭活疫苗加强免疫后抗体反应及流行病学效果[J]. 中国媒介生物学及控制杂志.
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