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Research progress on the regulation of mosquito-borne virus transmission by mosquito salivary proteins

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  • School of Medicine, Tsinghua University, Beijing 100084, China

Received date: 2021-08-30

  Online published: 2021-12-15

Abstract

Mosquito-borne viruses (MBVs) are the viruses mainly transmitted by mosquito bites. They are diverse and belong to various virus families. MBV infections are widely prevalent in many countries and regions around the world, posing great harms to public health and social economic development. When mosquitoes bite mammals, they not only inoculate the viruses locally in the skin, but also release many salivary components with significant biological activity, among which the most abundant and functional ones are salivary proteins. There are more than 100 types of proteins in mosquito saliva. These salivary proteins can not only inhibit blood coagulation and promote blood-sucking, but also significantly regulate the local and systemic immune and inflammatory reactions of mammalian hosts to regulate the transmission of MBVs to the hosts. This paper reviews the regulatory effect of mosquito salivary proteins on the immune system of mammalian hosts and MBV transmission, points out the scientific problems to be solved in the future, and finally introduces the current status and challenges of research on MBV blocking vaccines that target mosquito salivary proteins.

Cite this article

WANG Zhao-yang, CHEN Xiao-fang, CHENG Gong . Research progress on the regulation of mosquito-borne virus transmission by mosquito salivary proteins[J]. Chinese Journal of Vector Biology and Control, 2021 , 32(6) : 653 -659 . DOI: 10.11853/j.issn.1003.8280.2021.06.001

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