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Chines Journal of Vector Biology and Control
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ZHU Li-hua; ZHAO Tong-yan; DONG Yan-de; et al
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朱礼华;赵彤言;董言德;陆宝麟
Abstract: Objective:To understand the mechanisms of Den-2 virus infection on Balb/C laboratory mice.Methods:The laboratory mice were injected intravenously in its abdoman with a defined titers of Den-2 virus.Results:It showed Balb/C laboratory mice could be infected with Den-2 virus,although it was not the susceptible host of dengue virus.It can develop a 1-2 days detectable viremia,Den-2 antibody can be detected in the 4thday after injected.In the first two days,the infection rates of macrophages in abdomical cavity were high,but dropped rapidly.4 days later,the rates were very low.Conclusion:Balb/C laboratory mice can be used for study on the animal model infected with Den-2 virus.
摘要: 目的:探讨Balb/C小鼠作为实验动物模型感染登革病毒的情况。方法:小鼠腹部皮下多点注射接种大剂量登革病毒后在一定时间内检测血清病毒、抗体及腹腔巨噬细胞、脾细胞登革病毒感染情况。结果:Balb/C实验小鼠接种感染登革病毒以后能产生1~2d病毒血症,接种后第4d血清中即可检测到特异性抗体,说明在登革病毒感染早期即产生可检测到的特异性抗体,而腹腔巨噬细胞在接种后前1~2d登革病毒感染率较高,但下降很快,第4d以后感染水平很低,小鼠脾细胞登革病毒感染率极低,几乎检测不到阳性。结论:Balb/C实验小鼠可以用于实验感染登革Ⅱ型病毒
关键词: 登革病毒, 实验小鼠, 实验感染
ZHU Li-hua; ZHAO Tong-yan; DONG Yan-de; et al. Studies on Den-2 Virus In fection in Balb/C Laboratory Mice[J]. Chines Journal of Vector Biology and Control.
朱礼华;赵彤言;董言德;陆宝麟. 登革Ⅱ型病毒感染Balb/C实验小鼠的研究[J]. 中国媒介生物学及控制杂志.
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