Review

Research progress of RNA interference technology applied to vector control

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  • 1. National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese National Tropical Diseases Research Center) Vector-Borne Tropical Diseases Department, Shanghai 200025, China;
    2. School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China;
    3. Global Health Institute, Shanghai Jiao Tong University School of Medicine (Chinese Center for Tropical Diseases Research), Shanghai 200025, China

Received date: 2024-04-12

  Online published: 2025-03-05

Supported by

National Key Research and Development Program of China (No. 2021YFC2300800, 2021YFC2300802);National Natural Science Foundation of China (No. 82161160343)

Abstract

RNA interference (RNAi) is an efficient molecular regulatory method that specifically reduces the expression levels of target genes, thereby affecting the biological characteristics of pests. Mosquitoes, ticks, freshwater snails, and mites are key vectors for the transmission of various deadly diseases. RNAi has shown great potential in the control of vectors. This article reviews the application of RNAi technology in gene function research of mosquitoes, ticks, freshwater snails, and mites, especially the genes that affect reproductive capacity, growth and development, neural and metabolic functions, as well as immune response and virus transmission. In addition, the article discusses various factors that affect the efficiency of RNAi, including dsRNA length, concentration, administration route, and transfection methods. This article addresses the challenges faced by RNAi technology in practical applications and the potential of RNAi technology in vector control. The results provide new approaches and methods for advancing future vector control management strategies.

Cite this article

ZHANG Jian, GUO Yun-hai, KAI Zhen-peng, JIANG Tian-ge, ZHANG Yi . Research progress of RNA interference technology applied to vector control[J]. Chinese Journal of Vector Biology and Control, 2025 , 36(1) : 129 -136 . DOI: 10.11853/j.issn.1003.8280.2025.01.022

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