Review

Research advances in mosquito resistance to insecticides mediated by cytochrome P450

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  • 1 School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250062, Shandong Province, China;
    2 Shandong Institute of Parasitic Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences

Received date: 2019-04-18

  Online published: 2019-10-20

Supported by

Supported by the National Natural Science Foundation of China (No. 81672059, 81871685), Shandong Province Key Research and Development Projects (No. 2018GSF118040, 2019GSF111006) and the Innovation Project of Shandong Academy of Medical Sciences

Abstract

Cytochrome P450 is an important family of enzymes ubiquitously expressed in organisms. It can metabolize a variety of endogenous and exogenous substances, and plays an important role in the metabolism and detoxification of insecticides in insects. The metabolism and detoxification of insecticides mediated by P450 are characterized by universality and cross resistance, and the mechanisms involve an increase in enzyme expression and a change in enzyme activity. This article reviews some new research advances in the P450-mediated insecticide resistance of mosquitoes.

Cite this article

WANG Yang, SONG Xiao, CHENG Peng, GONG Mao-qing . Research advances in mosquito resistance to insecticides mediated by cytochrome P450[J]. Chinese Journal of Vector Biology and Control, 2019 , 30(5) : 589 -592 . DOI: 10.11853/j.issn.1003.8280.2019.05.027

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