Objective To investigate the seroprevalence of immunoglobulin G (IgG) antibodies in dengue cases nine years after being infected with dengue virus and associated factors, and to provide a scientific basis for dengue prevention and control. Methods A seroprevalence survey was conducted on dengue cases from a dengue outbreak (dengue virus-3) in Yiwu, Zhejiang province, China, 2009. Serum samples were collected from them from May to August, 2018 for dengue virus IgG antibody detection by ELISA. The distribution of dengue virus IgG antibodies in the serum samples was calculated, and associated factors for positive dengue virus IgG antibodies were analyzed. Results A total of 126 serum samples from dengue cases were collected and the mean seroprevalence of dengue virus IgG antibodies was 79.37% (100/126). The seroprevalence of males and females was 75.00% (30/40) and 81.40% (70/86), respectively, showing no significant difference (χ2=0.682, P=0.409). The seroprevalence in the groups aged 1-, 21-, 41-, and ≥ 61 years were 100%, 94.12%, 85.42%, and 67.86%, respectively; there was a significant difference in the seroprevalence of dengue virus IgG antibodies between the four groups (χ2=9.161, P=0.027). The seroprevalence of dengue virus IgG antibodies in apparent infection cases was significantly higher than that in inapparent infection cases (89.11% vs 40.00%, χ2=29.511, P=0.000). Conclusion Dengue virus IgG antibodies are detectable in dengue cases nine years after infection. The seroprevalence of dengue virus IgG antibodies in apparent cases is significantly higher than that in inapparent cases.
LUO Shu-ying, LIU Ying, FU Tao, SUN Ji-min
. An investigation of seroprevalence of IgG antibodies in infected cases nine years after a dengue outbreak[J]. Chinese Journal of Vector Biology and Control, 2019
, 30(4)
: 371
-373
.
DOI: 10.11853/j.issn.1003.8280.2019.04.003
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