Objective To understand the present situation and trend of resistance in Musca domestica to four types of insecticides in Dongli district of Tianjin in recent years, and to provide a scientific basis for better use of insecticides. Methods Musca domesticas were collected outdoors in Dongli district during 2014 to 2017, the resistance of M. domestica to β-cypermethrin, deltamethrin, permethrin and propoxur were determined by topical application method, and data were analyzed by SPSS 19.0 software for LD₅₀ and its confidential intervals (CI). The regression equation was established to evaluate resistance development trend. Results The resistance ratios of M. domestica in Dongli district during 2014 to 2017 to β-Cypermethrin, deltamethrin, permethrin and propoxur were 1.75-3.75, 1.00-15.00, 36.75-40.00, and 3.41-29.50 fold, respectively. Musca domestica in Dongli district has developed severe resistance to permethrin and propoxur, moderate to deltamethrin, and mild even susceptible to β-Cypermethrin. Conclusion Musca domestica in Dongli district of Tianjin has developed different degrees of resistance to four types of insecticides and the trend was upward. It is suggested that insecticides should be used scientifically based on the susceptibility monitoring, in order to prevent and delay the development of resistance.