Objective To understand the pathogen's epidemiological origination and molecular characteristics of the dengue fever case in Quzhou city, Zhejiang. Methods The epidemiological survey was conducted and the serum sample was collected from the imported dengue fever patient in 2017 to detect dengue virus nucleic acids and antibody. The envelope (E) gene of the virus was amplified and sequenced. The genotype of the isolate was analyzed with bioinformatics software. Results The serum sample of the patient was positive for dengue virus nucleic and anti-dengue IgM. The homologous and phylogenetic analysis showed that the isolate belonged to dengue virus type 1, and the sub genotype was GI. It had a closest phylogenetic relationship with the strain isolated from the case of Southeast Asia (accession number KY586429.1, KJ806941.2), sharing 99.1% and 99.7% homology in nucleotide sequence and amino acid sequence respectively, indicating that it might have originated from the Southeast Asia. Conclusion The imported dengue fever case in Quzhou city might be contracted from the Southeast Asia.
YANG Rui-jun, HUANG Shi-teng, WANG Xiao-guang, LYU Lei, CAO Guo-ping, WAN Sheng, YE Cheng-hua, CHEN Xu-fu
. Molecular epidemiological studies on an imported dengue fever case in Quzhou city, Zhejiang[J]. Chinese Journal of Vector Biology and Control, 2018
, 29(5)
: 445
-447
.
DOI: 10.11853/j.issn.1003.8280.2018.05.006
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