Objective To develop the long-acting mosquito repellent ointment and evaluate its slow-release performance and repellent effect on mosquitoes. Methods The mosquito Aedes albopictus was collected from the animal sheds of Fuzhou General Hospital of Fujian province during hours of 16:00-05:00 during spring and summer. The sustained release properties of long acting mosquito repellent ointment were evaluated by the percentage of volatile residue. Indoor test was carried out by national method "GB/T 13917.9-2009 laboratory efficacy test and evaluation of sanitary insecticides for pesticide registration", and the repellent effect and average protection time of mosquitoes were calculated. Results The homemade mosquito repellent ointment released DEET faster than the commercially available mosquito repellent cream by The Second Military Medical University, but it could also sustained releasing up to 12 h. The average indoor protection time of the DEET tincture was(3.98±1.14) h, the average indoor mean protection time of a commercially available mosquito repellent cream by The Second Military Medical University was(9.78±2.38) h, the average time for the protection of homemade mosquito repellent ointment was(10.11±2.22) h. Conclusion The self-made mosquito repellent ointment was better than the DEET tincture and the commercially available mosquito repellent cream by The Second Military Medical University.
WANG Jia-lin, YUN Chao, ZENG Ling-jun, TAO Chun, SONG Hong-tao
. Development and evaluation on long acting mosquito repellent ointment[J]. Chinese Journal of Vector Biology and Control, 2018
, 29(4)
: 400
-402
.
DOI: 10.11853/j.issn.1003.8280.2018.04.021
[1] Fournier PE,Roux V,Caumes E,et al.Outbreak of Rickettsia africae infections in participants of an adventure race in South Africa[J].Clin Infect Dis,1998,27(2):316-323.DOI:10.1086/514664.
[2] Norris EJ,Coats JR.Current and future repellent technologies:the potential of spatial repellents and their place in mosquito-borne disease control[J].Int J Environ Res Public Health, 2017,14(2):124.DOI:10.3390/ijerph14020124.
[3] 禤砾.漫话植物源昆虫驱避剂[J].世界农药,2002,24(2):20-22,5.DOI:10.3969/j.issn.1009-6485.2002.02.005.
[4] Frances SP.Efficacy and safety of repellents containing deet[M]//Debboun M,Frances SP,Srtickman D.Insect Repellents:Principles,Methods,and Uses.Boca Raton:CRC Press,2007:311-325.
[5] Goodyer LI,Croft AM,Frances SP,et al.Expert review of the evidence base for arthropod bite avoidance[J].J Travel Med, 2010,17(3):182-192.DOI:10.1111/j.1708-8305.2010.00402.x.
[6] De Gennaro M.The mysterious multi-modal repellency of DEET[J].Fly,2015,9(1):45-51.DOI:10.1080/19336934.2015.1079360.
[7] Swale DR,Sun BN,Tong F,et al.Neurotoxicity and mode of action of N,N-diethyl-meta-toluamide(DEET)[J].PLoS One, 2014,9(8):e103713.DOI:10.1371/journal.pone.0103713.
[8] Diaz JH.Chemical and plant-based insect repellents:efficacy, safety,and toxicity[J].Wilderness Environ Med,2016,27(1):153-163.DOI:10.1016/j.wem.2015.11.007.
[9] Ciocchetta S,Darbro JM, Frentiu FD, et al.Laboratory colonization of the European invasive mosquito Aedes(Finlaya) koreicus[J].Parasit Vectors,2017,10:74.DOI:10.1186/s13071-017-2010-2.
[10] Lees RS,Knols B,Bellini R,et al.Review:improving our knowledge of male mosquito biology in relation to genetic control programmes[J].Acta Trop,2014,132 Suppl:S2-11.
[11] Le Goff G,Goodman SM,Elguero E,et al.Survey of the mosquitoes (Diptera:Culicidae) of Mayotte[J].PLoS One, 2014,9(7):e100696.DOI:10.1371/journal.pone.0100696.
[12] Facchinelli L,Valerio L,Lees RS,et al.Stimulating Anopheles gambiae swarms in the laboratory:application for behavioural and fitness studies[J].Malar J,2015,14:271.DOI:10.1186/s12936-015-0792-2.
[13] Kampen H,Medlock JM,Vaux AG,et al.Approaches to passive mosquito surveillance in the EU[J].Parasit Vectors,2015,8:9.DOI:10.1186/s13071-014-0604-5.
[14] Hsu HY, Harris MT, Toth S, et al.Drop printing of pharmaceuticals:effect of molecular weight on PEG coated-naproxen/PEG3350 solid dispersions[J].AIChE J,2015,61(12):4502-4508.DOI:10.1002/aic.14979.