Objective To study the epidemic intermittent period of plague natural foci which wound play an important role in the prevention and control of plague in Hebei province. Methods Meriones unguiculatus were caught by diurnal method and Citellus dauricus were investigated by the one-day bow clip capture from 1981 to 2013 in the natural foci of plague in Hebei province. The density of host animal plague was calculated. Historical data was consulted and the epidemic year was determined. Results The plague was found in 1971 in Hebei province. There were 4 animal plague epidemics from 1971 to 2015. There were 8 epidemic years, namely, 1971, 1972, 1984, 1994, 1995, 2002, 2003, and 2005. The average gap was 10 years. Conclusion The epidemic period of about 10 years of plague exists in the natural focus of the plague of Hebei province.