Objective To monitor the resistance level of Musca domestica to different types of insecticides in Hebei province, China, understand the resistance characteristics and development trend. The changes of resistance to different insecticides were compared in the laboratory without selection pressure, to provide reference for effective chemical control. Methods During 2012-2016 in Hebei province, 83 sampling sites, such as garbage site, farmers market and other breeding sites were selected in 11 cities (districts). Adult houseflies were collected by net trapping, and reared for 1-2 generations in the laboratory, 3-5 days old female adults were used for assay. The resistance level to different types of insecticides was determined by the method of drip method, and the trend of resistance of M. domestica was analyzed by comparing the historical data. Results Musca domestica in Hebei province showed moderate to high levels of resistance to pyrethroid, the degree of resistance varied with organophosphorus, carbamate, and organochlorine. In comparison with the historical data, it was found that the resistance to DDVP declined, then gradually, steadily and slightly increased. Resistance to permethrin significantly increased. The average decline of resistance to permethrin, beta-cypermethrin and DDVP was 90.39%, 89.23%, and 80.41%, after 59 generations in the laboratory in the absence of pesticide selection. Conclusion Musca domestica in Hebei province had different degrees of resistance to four types of insecticides, and the resistance levels to permethrin, cypermethrin, and DDVP declined at varied magnitudes.