Objective To compare field rodent control efficacy using various methods and provide scientific data for deratization in the future. Methods To observe the change of rat density before and after deratizatio at the experimental animal center from September to November 2015. Glue rat board was continuously used in the finished feed warehouse, using bromadiolone baits in raw material storehouse, production workshop using the mousetrap method, the conventional animals feeding chamber by cage-trap. Results A total of 122 rats were captured in 18 d, after deratization average rat density dropped to 6.8% from 59.1% prior to the deratization; corrected deratization rate was 79.2%. Peak was in first day by three physical deratization methods, after a downward trend, the rat density were significantly lower after deratization, but did not reach the standard (≤3%). Dead rats were found after 3 d using bromadiolone baits, 5-6 d to peak, rat density decreased to 0 after deratization. Conclusion Various methods used for prevention and control of rodents obviously reduced the density of rodents. The deratization methods which fit different environments were screened according to the feeding habit, in order to choose rodent bait and control devices efficiently.