Objective To monitor the resistance status of Culex pipiens pallens to commonly used insecticides in Hohhot city and the surrounding areas for management of insecticide resistance development. Methods The susceptibility of larvae to five commonly used insecticides was tested by WHO larval immersion method to determine the median lethal concentration (LC₅₀) and 95% confidence intervals (95%CI). Results In Hohhot city, Qingshuihe, Wuchuan, Tuoketuo, Helingeer county, and Tumed Left Banner, the resistance ratios of Cx. pipiens pallens for deltamethrin were 1.09, 0.05, 0.77, 0.09, 0.87, and 0.09 fold; for permethrin were 0.97, 0.09, 0.63, 0.11, 1.16, and 0.07 fold; for beta cypermethrin were 1.18, 0.08, 0.19, 0.01, 0.08, and 0.06 fold; for parathion were 1.22, 0.73, 7.96, 0.68, 1.21, and 1.37 fold; for DDVP were 5.02, 0.89, 0.01, 0.09, 1.06, and 0.17 fold, respectively. Conclusion Culex pipiens pallens in Hohhot city and the surrounding areas is overall susceptible to above five commonly used insecticides, except that Cx. pipiens pallens in Wuchuan country and Hohhot city have low resistance to parathion and DDVP, respectively.