Objective To investigate the epidemic status of schistosomiasis in Zhejiang province, so as to provide scientific data for the strategies for schistosomiasis control. Methods The snail survey was conducted by the method of five meter synchronously systematic samplings combined with the environmental samplings. The snails were dissected to determine the infection status and were controlled by molluscacide combined with environmental modification. Both residents, migrating population and domestic animals were screened by serological methods, and the positive cases were confirmed by miracidium hatching method. Results The snail-infestation area was 657 200 m² in 328 villages of 94 towns in Zhejiang province in 2015. Among them, the area of 8 600 m² was newly detected. No infection was found among 78 428 snails dissected. In total 112 800 individuals were examined by serological methods, and 679 persons were positive and the positive rate is 0.60%. No native cases or livestock were found except 8 imported cases. 1 119 advanced patients were treated and medical care provided. Conclusion The results of surveillance showed the current stable schistosomiasis endemics in Zhejiang province. However, a risk factor for re-emergence of schistosomiasis still exists. Comprehensive strategy including emphasizing on prevention and control of residual snail and import cases should be stressed in the future.