Objective To analyze epidemiological characteristics of severe fever with thrombocytopenia syndrome(SFTS) cases from Dandong city in 2010-2015, and to provide basis for the prevention and control measures. Methods The laboratory-confirmed cases reported by information management system in Dandong city from 2010-2015 were analyzed through descriptive epidemiology. Results From 2010 to 2015, 101 cases of SFTS in laboratory confirmed cases were reported in Dandong city. Of these cases, 5 cases died and the mortality rate was 4.95%. The onset time of the disease was mainly from May to October,and the peak time was from June to September. The cases were distributed in 5 counties(or cities), 37 villages and towns. The prevalent area is from the mountainous and hilly regions to the plain areas. From 2010 to 2014, males, middle-aged or older persons and farmers were the main infected persons each year, and in 2015, middle-aged and young women in the countryside were frequently infected. Thirty-two cases of the disease were once ever bitten by some kind of ticks before the onset, and 2 cases were brother and sister and once had blood contact. The main symptoms were fever, body aches,headache, fatigue, nausea, abdominal pain, diarrhea and joint pain. Conclusion The onset of SFTS has obvious regional and seasonal characteristics and it was widely distributed in Dandong city. Besides, in 2015, the incidence population changed. As a result, comprehensive prevention and control measures should be taken to prevent and control the disease.