Objective To investigate the effects of the establishment of the dengue fever prevention and control demonstration area on the government capacity of mass prevention and control and to explore sustainable prevention and control measures, so as to set up the foundation for the preventive strategies and measures for mosquito-borne diseases. Methods Chancheng District Government, Bureau of Health and Family Planning Commission at sub-district and town levels, Office of Patriotic Health Campaign Committee,and local villagers' committees and neighborhood committees were selected and reviewed for the investigation and assessment of dengue response capacity. Statistical analysis was conducted with SPSS 19.0 software. Chi-square test was used for the comparison of univariate analysis, while t-Test was applied for the comparison between two independent sample means. Results From Chancheng district government to its subordinate towns and sub-districts, the leadership establishment, the establishment of health emergency response system, the logistics support, the budget planning and supervising mechanisms were all put in place accordingly before and after the construction of the demonstration area. After the establishment of the demonstration area, the proportions of the organizational structure and the contingency planning management on the level of villagers' committee and neighborhood committee have been increased significantly(χ²=22.510, 47.890, P<0.05). The proportions of the establishment of emergency response team,the exercises of contingency drill,the strategic contingency material reservation and the implementation of supervising mechanisms(93.38%, 36.03%, 61.76%, 85.29%, and 51.47%)were all higher than the conditions before the establishment of the Demonstration Area,with statistically significant differences(χ²=9.890, 44.180, 63.520, 37.330, 52.270, P<0.05). Also, disinfection personnel of local villagers' committees and neighborhood committees increased from 4 people in 2014 to 7 people in 2015,with statistically significant difference(t=-3.600, P<0.05). Conclusion The establishment of dengue fever prevention and control demonstration area in Chancheng district improved the governmental capacity of mass prevention and control,established a normal mechanism of mass prevention and control, carried out the mosquito vector control projects efficiently, and mitigated the epidemics locally.