Objective To summarize the epidemic status of malaria and the experience of malaria control in Yongkang city, Zhejiang province, during 1950 and 2013, to evaluate the effect of malaria prevention and control, and to discuss the feasibility of malaria eradication. Methods On a review of malaria control process, this paper summarized the measures applied for the control of malaria epidemic. Results The vivax malaria was highly epidemic before 1980s. The highest annual morbidity was 74.09 per million. The morbidity since 1987 was under 1 per million. In 1987 we reached the standard that malaria were basically eradicated and came into the monitoring phase. The malaria morbidity fell year by year, and the imported cases was on rise, but secondary cases were not found. The malaria morbidity was under 0.1 per million in 2009. The controlling process can be divided into 4 stages including focus on the investigation and study on the pilot prevention, disease control, reduction of the morbidity, and consolidation, with appropriate control measures for each stage. Conclusion Prevention and treatment experience of 64 years has laid the foundation for the eradication of malaria in Yongkang city, Zhejiang province. Our goal of malaria eradication in 2015 is achievable if the following efforts are in place: health education for the migrating human population, efforts to improve the malaria detection, collaboration among more entities, timely management of human cases.