Objective To observe the efficacy of four organophosphorus pesticides in killing the wild population of Cimex lectularius. Methods Pesticide coated jam bottles were used in the study; three concentrations of each of four pesticides were spread on the inner walls and bottoms of wide mouth bottles, and acetone solvent was used as a control. Cimex lectularius was put into the bottles and continuously exposed to the pesticides until death. Results For different concentrations of pesticides, the median lethal times of wild population of C. lectularius were 15.3, 18.4, and 20.2 min for dichlorovos, 220.5, 290.7, and 231.3 min for fenthion, 230.7, 335.9, and 1300.0 min for phoxim, and 490.5, 475.3, and 460.0 min for fenitrothion. Dichlorvos had the highest insecticidal efficacy, followed by phoxim, fenthion, and fenitrothion. Conclusion Among the four tested pesticides, phoxim is recommended to be the preferred one. Dichlorvos may be used in case of emergency.