Chines Journal of Vector Biology and Control ›› 2019, Vol. 30 ›› Issue (6): 696-698.DOI: 10.11853/j.issn.1003.8280.2019.06.024

• Investigation • Previous Articles     Next Articles

Epidemiological and clinical features of avian influenza A (H7N9) virus infection in humans in Hangzhou, China: an analysis of 96 cases

REN Xiao-bin, SUN Zhou, WANG Jing, YANG Xu-hui, LIU Mu-wen, KAO Qing-jun, ZHU Lei   

  1. Hangzhou Center for Disease Control and Prevention, Hangzhou 310021, Zhejiang Province, China
  • Received:2019-08-05 Online:2019-12-20 Published:2019-12-20

杭州市96例人感染H7N9禽流感病例临床流行病学特征分析

任晓宾, 孙昼, 王婧, 杨旭辉, 刘牧文, 考庆君, 朱雷   

  1. 杭州市疾病预防控制中心传染病防制所, 浙江 杭州 310021
  • 作者简介:任晓宾,男,硕士,主管医师,主要从事传染病的预防与控制工作,Email:183268943@qq.com

Abstract: Objective To investigate the epidemiological and clinical features of avian influenza A (H7N9) virus infection in humans in Hangzhou, China, and to provide a scientific basis for the prevention and treatment of avian influenza A (H7N9) virus infection. Methods Related clinical data were collected from the patients with avian influenza A (H7N9) virus infection in Hangzhou from 2013 to 2018. EpiData 3.1 database was used for data entry, and SPSS 16.0 softuare was used for statistical analysis. The chi-square test was used for comparison of mortality rate between groups. Results A total of 96 confirmed cases of avian influenza A (H7N9) virus infection were reported in Hangzhou from 2013 to 2018, among whom 33 patients died, resulting in a mortality rate of 34.38%. There were 5 waves of H7N9 epidemics in Hangzhou, and there was no significant difference in mortality rate between the five waves (χ2=6.131, P=0.190). There were 47 patients in the urban area with 14 deaths (29.79%) and 49 patients in the rural area with 19 deaths (38.78%), and there was no significant difference in mortality rate between the two groups (χ2=0.859, P=0.354). There were 64 male patients with 21 deaths (32.81%) and 32 female patients with 12 deaths (37.50%), and there was no significant difference in mortality rate between the two groups (χ2=0.208, P=0.649). There were 49 patients in the age <60 years group with 10 deaths (20.41%) and 47 in the age ≥ 60 years group with 23 deaths (48.94%), and there was a significant difference in mortality rate between the two groups (χ2=8.655, P=0.003). There was no significant difference in mortality rate between the groups with different occupations (χ2=5.728, P=0.126). A total of 52 patients had underlying diseases, among whom 25 died, with a mortality rate of 48.08%; 43 patients had no underlying diseases, among whom 7 died, with a mortality rate of 16.28%; there was a significant difference in mortality rate between the two groups (χ2=10.654, P=0.001). Conclusion Patients with avian influenza A (H7N9) virus infection who have an older age and underlying diseases tend to have a high mortality rate and thus they are the key population for the prevention and treatment of avian influenza.

Key words: Avian influenza (H7N9), Epidemiology, Analysis

摘要: 目的 分析杭州市2013-2018年人感染H7N9禽流感病例临床流行病学特征,为H7N9禽流感的治疗和预防提供科学依据。方法 收集2013-2018年杭州市人感染H7N9禽流感病例临床资料,使用EpiData 3.1数据库录入数据,应用SPSS 16.0软件进行统计学分析,对不同组别间病死率的比较采用χ2检验。结果 2013-2018年杭州市累计报告确诊人感染H7N9禽流感病例96例,死亡33例,病死率为34.38%。杭州市共经历5个流行季,5个流行季的疫情病死率差异无统计学意义(χ2=6.131,P=0.190);城区病例47例,死亡14例,病死率为29.79%,农村病例49例,死亡19例,病死率为38.78%,两组病死率差异无统计学意义(χ2=0.859,P=0.354);男性病例64例,死亡21例,病死率为32.81%,女性32例,死亡12例,病死率为37.50%,两组病死率差异无统计学意义(χ2=0.208,P=0.649);60岁以下年龄组病例49例,死亡10例,病死率为20.41%,60岁及以上年龄组病例为47例,死亡23例,病死率为48.94%,两组病死率差异有统计学意义(χ2=8.655,P=0.003);不同职业组间病死率差异无统计学意义(χ2=5.728,P=0.126);有基础疾病的病例52例,死亡25例,病死率为48.08%,无基础疾病的病例43例,死亡7例,病死率为16.28%,差异有统计学意义(χ2=10.654,P=0.001)。结论 高年龄组和有基础疾病的人群感染H7N9禽流感病例病死率较高,是禽流感防治的重点人群。

关键词: H7N9禽流感, 流行病学, 分析

CLC Number: