Research progress in molecular mechanisms of vector insect's resistance to insecticides

doi:10.11853/j.issn.1003.8280.2018.06.029

Abstract

Abstract: Studies on the mechanisms of insect's resistance to insecticides are extremely significant to the management of vector insects, the monitoring of insecticide resistance, as well as the development of new insecticides. The research of insect's resistance mechanisms has made a breakthrough, recently, with the application of insect genomics, proteomics, genetics and molecular biology, there is a deeper understanding of physiological metabolism, resistance behavior, target-site and the relationship between structure and function of insects. It has been confirmed that insect's resistance is mainly related to enhanced detoxification metabolism and decreased target sensitivity, it rooted from genetic changes, including gene amplification, structure mutation and expression up-and down-regulation. This paper reviewed the progress of vector insect's resistance to insecticidesat the molecular level.

Key words: Vector insects, Insecticide resistance, Metabolic resistance, Target-site resistance, Gene

摘要： 昆虫抗药性机制的研究对病媒昆虫治理、抗药性监测及新型杀虫剂研发意义重大。近年来，随着昆虫基因组学、蛋白质组学、遗传学与分子生物学的应用，昆虫抗药性机制的研究已取得突破性进展，人们对昆虫的生理代谢、杀虫剂作用靶标、抗性行为等有了更深入的理解。研究表明，昆虫抗药性主要与解毒代谢增强、靶标敏感性降低有关，其本质源于基因变化，包括基因异常扩增、基因结构突变及表达水平改变等。该文对病媒昆虫抗药性机制的研究进行了分子水平的综述。

关键词: 病媒昆虫, 抗药性, 靶标抗性, 代谢抗性, 基因

CLC Number:

SONG Xiao, SHI Qi-qi, CHENG Peng, GONG Mao-qing. Research progress in molecular mechanisms of vector insect's resistance to insecticides[J]. Chines Journal of Vector Biology and Control, 2018, 29(6): 657-661.

宋晓, 史琦琪, 程鹏, 公茂庆. 病媒昆虫的抗药性分子机制研究进展[J]. 中国媒介生物学及控制杂志, 2018, 29(6): 657-661.

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