Chines Journal of Vector Biology and Control ›› 2017, Vol. 28 ›› Issue (6): 553-556.DOI: 10.11853/j.issn.1003.8280.2017.06.009

Previous Articles     Next Articles

Host rodent and gene characteristics of Hantavirus in main endemic areas of hemorrhagic fever with renal syndrome in Hebei province

WANG Yan, WEI Ya-mei, HAN Xu, HAN Zhan-ying, CAI Ya-nan, QI Shun-xiang, LI Qi   

  1. Hebei Center for Disease Control and Prevention, Shijiazhuang 050021, Hebei Province, China
  • Received:2017-06-22 Online:2017-12-20 Published:2017-12-20
  • Supported by:
    Supported by the Natural Science Foundation of Hebei Province of China(No. H2015303009)

河北省肾综合征出血热疫区鼠类构成及其携带汉坦病毒调查

王妍, 魏亚梅, 韩旭, 韩占英, 蔡亚男, 齐顺祥, 李琦   

  1. 河北省疾病预防控制中心病毒病防治所, 石家庄 050021
  • 通讯作者: 李琦,Email:liqinew@aliyun.com
  • 作者简介:王妍,女,在读硕士,主要从事疾病预防与控制研究,Email:wychild@126.com
  • 基金资助:
    河北省自然科学基金(H2015303009)

Abstract: Objective To investigate the distribution and the gene characteristics of Hantavirus (HV) carryied by rodents in the epidemic area of hemorrhagic fever with renal syndrome (HFRS). Methods According to the distribution of hemorrhagic fever in Hebei province, six areas were selected as the focus research areas. The residential area and the field of six regions above were sampled respectively and night trap method was used for catching the rodents. The multiplex genotype RT-PCR was used to detect the HV genotype. Results During 2015 and 2016, the field average rodent density was 0.44%, and residential average rodent density was 2.77%. The difference was statistically significant (χ2=317.995, P<0.001). Rattus norvegicus was the predominant in residential areas and field, accounted for 84.12% and 92.50% of the total catch, respectively. The average positive rate was about 2.85% (35/1 228), the positive rate of the rodent in residential area was about 2.98% (33/1 108), the rate of rodent with virus was 1.67% (2/120), the positive rate of rodent in residential area was higher than that in the field, the difference was statistically significant (χ2=37.780, P<0.05). All viral isolates belonged to SEOV. Conclusion Rattus norvegicus was predominant species, which is the main source of infection of local HFRS. SEOV was the predominant genotype carried by host animals.

Key words: Hemorrhagic fever with renal syndrome, Rodent host, Hantavirus, Infection status

摘要: 目的 了解肾综合征出血热(HFRS)疫区鼠类分布及其携带汉坦病毒(HV)状况。方法 2015-2016年根据河北省HFRS疫区分布情况,选择6个县(区)为重点研究区域,在居民区和野外采用夹夜法捕鼠;利用多重荧光定量RT-PCR检测HV携带情况。结果 2015-2016年6个区域的野外和居民区平均鼠密度分别为0.44%和2.77%,差异有统计学意义(χ2=317.995,P < 0.001);居民区和野外的优势鼠种均为褐家鼠,分别占其总捕获数的84.12%和92.50%;鼠带病毒率为2.85%(35/1 228),其中居民区鼠带病毒率为2.98%(33/1 108),野外为1.67%(2/120),居民区鼠带病毒率高于野外,差异有统计学意义(χ2=37.780,P < 0.05);带病毒鼠携带病毒均为汉城型汉坦病毒(SEOV)。结论 褐家鼠是河北省HFRS疫区的优势鼠种,是当地HFRS的主要传染源;鼠类宿主动物携带的HV基因型为SEOV。

关键词: 肾综合征出血热, 鼠类宿主, 汉坦病毒, 感染状况

CLC Number: