Resistance of Rattus norvegicus to the anticoagulant rodenticides in Chengdu

Chines Journal of Vector Biology and Control ›› 2012, Vol. 23 ›› Issue (3): 239-241.

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Resistance of Rattus norvegicus to the anticoagulant rodenticides in Chengdu

DENG Liang-li¹, MA Lin¹, SUN Yi², SHI Wei¹, TIAN Wen-jia¹, HE Jian-han¹, LIAO Jun¹, XIAO Lin¹, LIU Zhu¹, ZHANG Jing¹, JIANG Zheng¹

1 Chengdu Center for Disease Control and Prevention, Chengdu 610041, Sichuan Province, China;
2 Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences

Received:2011-11-24 Online:2012-06-20 Published:2012-06-20
Supported by:
Supported by the 2010 Chengdu Municipal Health Bureau Funded Research Projects(No.［2010］50)

成都地区褐家鼠种群对抗凝血类杀鼠剂的抗药性水平

邓良利¹, 马林¹, 孙毅², 时炜¹, 田汶佳¹, 何建邯¹, 廖骏¹, 肖霖¹, 刘竹¹, 张静¹, 蒋峥¹

1 成都市疾病预防控制中心消毒与病媒生物控制科, 四川成都 610041;
2 军事医学科学院微生物流行病研究所

通讯作者: 马林,Email: 236631285@qq.com
基金资助:
成都市卫生局2010年资助科研课题(成卫科教［2010］50号)

Abstract

Abstract: Objective To Evaluate the resistance of Rattus norvegicus to warfarin and bromadiolone in Chengdu, providing information for the control of rodents in the area. Methods The resistance of R. norvegicus to warfarin and bromadiolone was tested with the BCR method. Results The 50% effective dose (ED50) of warfarin for R. norvigicus was 0.873 mg/kg for male and 1.439 mg/kg for female respectively, with that of bromadiolone being 1.091 mg/kg for male and 1.296 mg/kg for female. According to the baseline of susceptible R. norvegicus approved by ARRPC,the resistance level of the population was between 0.578 and 0.676 fold for warfarin and between 2.125 and 2.321 for bromadiolone. Conclusion R. norvigicus populations have developed resistance to bromadiolone in Chengdu, but not to warfarin, which can be used as an alternative rodenticide applicable to the control of rodents in Chengdu.

Key words: Rattus norvegicus, Insecticide resistance, Warfarin, Bromadiolone, Blood clotting reaction

摘要： 目的测定成都市褐家鼠种群对抗凝血类杀鼠剂的抗药性水平,为鼠害控制提供依据。方法采用凝血反应法测定褐家鼠对杀鼠灵和溴敌隆的抗药性。结果成都地区褐家鼠对杀鼠灵ED50为0.873(雄)和1.439(雌)mg/kg;对溴敌隆ED50为1.091(雄)和1.296(雌)mg/kg 。按照鼠药抗性委员会推荐的敏感褐家鼠基准,该鼠种群对杀鼠灵的抗性水平在0.578～0.676之间;对溴敌隆的抗性水平在2.125～2.321之间。结论成都地区褐家鼠种群对溴敌隆已产生抗药性,对杀鼠灵未产生抗药性;在鼠害治理中,杀鼠灵可作为替代药物。

关键词: 褐家鼠, 抗药性, 杀鼠灵, 溴敌隆, 凝血反应

CLC Number:

S443
S481.4

DENG Liang-li, MA Lin, SUN Yi, SHI Wei, TIAN Wen-jia, HE Jian-han, LIAO Jun, XIAO Lin, LIU Zhu, ZHANG Jing, JIANG Zheng. Resistance of Rattus norvegicus to the anticoagulant rodenticides in Chengdu[J]. Chines Journal of Vector Biology and Control, 2012, 23(3): 239-241.

邓良利, 马林, 孙毅, 时炜, 田汶佳, 何建邯, 廖骏, 肖霖, 刘竹, 张静, 蒋峥. 成都地区褐家鼠种群对抗凝血类杀鼠剂的抗药性水平[J]. 中国媒介生物学及控制杂志, 2012, 23(3): 239-241.

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Resistance of Rattus norvegicus to the anticoagulant rodenticides in Chengdu

成都地区褐家鼠种群对抗凝血类杀鼠剂的抗药性水平

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