Abstract:

This study introduces the origin of plague and analyzes the persistence of Yersinia pestis (plague bacillus) in the natural foci of plague. By describing the epidemiologic characteristics of epizootic plague and the revelatory elimination of plague origins in the 1970s, the study depicts the advancement in the research into the mechanisms of persistence of Y. pestis in nature, and raises a new hypothesis that during plague-free intervals, Y. pestis is preserved in nature through gene mutations on a long-term basis, forming a Y. pestis-host-vector trinity ecosystem.

Key words: Yersinia pestis, Mechanism of persistence, Research proceedings

摘要：

通过阐明鼠疫的起源，分析鼠疫耶尔森菌(鼠疫菌)在鼠疫自然疫源地内的保存学说，描述动物间鼠疫流行特征和20世纪70年代的灭鼠拔源工作带给我们的启示，揭示鼠疫菌在自然界保存机制的研究进展情况，提出在鼠疫流行间歇期内，鼠疫菌主要以基因突变的方式长期保存在自然界中，形成鼠疫菌-宿主-媒介三位一体的鼠疫生态系统的新学说，为我国鼠疫的防治提供科学的参考依据。

关键词: 鼠疫耶尔森菌, 保存机制, 研究进展