Abstract: Objective To study the control effect of different concentration of chlormadinone acetate on popalation expansion of mice,and the active duration and optimum concentration of chlormadinone acetate against mice.Methods Different concentrations of chlormadinone acetate were fed to mice in different time,and the quantity growth dynamics of mice was observed.Results The reproduction of female mice was controlled by 10 mg/kg chlormadinone acetate in the first month,and pregnancy of female mice was only 30% to 40% in the second and the third month.Quantity of mice decreased 70% to 80% after five to six months.Mice behaved as preference and the feeding index exceeded 1.0.Conclusion Chlormadinone acetate is of significance reproductive to block reprodnction of mice.The effective time lasts 3 months for taking 10 mg/kg chlormadinone acetate once.

摘要： 目的 研究不同浓度的醋酸氯地孕酮对小白鼠种群发展的控制效果,以及该药物控制鼠类的持效期和最适浓度。方法 不同浓度和不同时间饲喂小白鼠醋酸氯地孕酮饵料,观察该鼠实验种群的数量增长动态。结果 小白鼠口服10mg/kg醋酸氯地孕酮可完全控制当月雌鼠的生殖活动,第2个月和第3个月雌鼠的怀孕率也只有30%～40%,5-6个月后可减少鼠类数量70%～80%。鼠类喜食,摄食指数超过1.0。结论 醋酸氯地孕酮对小白鼠具有显著的生殖阻断作用,口服10mg/kg醋酸氯地孕酮1次的有效控制时间为3个月。

关键词: 醋酸氯地孕酮, 小白鼠, 种群, 控制效应