ISSN 1003-8280 CN 10-1522/R 中国疾病预防控制中心 主办
Chines Journal of Vector Biology and Control
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LI Yan-jin; LU Qun-ying; ZHU Zhi-yong; et al
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李岩金1;陆群英1;朱智勇1;赵丽娟2
Abstract: Objective:To observe the neutralizing antibody reaction after secondary immunization with Bivalent inactivated vaccine for epidemic hemorrhagic fever.Methods:Some volunteers were injected with bivalent inactivated vaccines for epidemic hemorrhagic fever(HFRS).3 doses were for primary immunization and one dose for secondary immunization after one and half year's interval.Neutralizing antibodies(NA)against HTNV and SEOV in sera before and after secondary immunization were detected by a plaque reduction neutralization test(PRNT).Result:TheGMT of NA against HTNV and NA against SEOV after secondary immunization were 1:28.29 and 1:32.49,respectively.The GMT of NA increased(3-10 fold)compared with that before secondary immunization.
摘要: 目的:双价肾综合征出血热(HFRS)灭活疫苗基础全程3针免后1年半加强1针免疫,观察两型的中和抗体反应水平。方法:对免疫志愿者加强免疫前和免疫后20d采血,以空斑减少中和试验(PRNT)检测血清中HFRSⅠ型(76-118)和Ⅱ型(SEOV)中和抗体。结果:血清学检测加强免疫后Ⅰ型中和抗体滴度GMT128.29,Ⅱ型中和抗体滴度为1:32.49,比加强免疫前两型中和抗体滴度高3~10倍。结论:加强免疫实属必要。
关键词: 双价肾综合征出血热灭活疫苗, 加强免疫, 中和抗体
LI Yan-jin; LU Qun-ying; ZHU Zhi-yong; et al. Neutralizing Antibody Reaction after Secondary Immunization with Bivalent Inactivated Vaccine for Epidemic Hemorrhagic Fever[J]. Chines Journal of Vector Biology and Control.
李岩金1;陆群英1;朱智勇1;赵丽娟2. 双价肾综合征出血热灭活疫苗加强免疫后中和抗体反应[J]. 中国媒介生物学及控制杂志.
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