ISSN 1003-8280 CN 10-1522/R 中国疾病预防控制中心 主办
Chines Journal of Vector Biology and Control
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MA Zhen-hong; CHEN Shu-yu; QU Ming-fang
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马桢红;陈淑玉;瞿明芳
Abstract: Objective:To evaluate repellent efficacy,fungistatic efficacy and safety of the camphor oil spray.Method:Place the human volunteer's hand treated with the camphor oil inside a cage containing 300 Aedes albopictus,for 2 min,and observe the treated skin surface for mosquitoes which landed and attempted to feed.Mingle the camphor oil and the fungous suspension,Candida albicans,culture and count the number of mold.Infuse the mice with the spray by single oral injection,and treat directly the rabbits'exposed skin and the conjunctiva crypt with the spray.Result:The repellent protection time against Aedes albopictuswas over 6h.Mean fungistatic rate to mold was99.99%.The acute oral LD50 was 1302.5 mg/kg in mice.This product was non-irritant to skin,but slightly irritant to eye.Conclusion:The camphor oil spray is a better repellency against mosquito,inhibitor against mold,and low acute toxicity substance.
摘要: 目的:评价樟脑油精喷剂的药效及其在使用中的安全性。方法:将樟脑油精涂于裸露皮肤上,进行驱蚊试验;取白色念球菌(ATCC10231)悬液加入樟脑油精,观察对真菌的抑制作用;急性经口毒性试验采用一次性灌胃给药;急性皮肤刺激和眼刺激试验直接涂药于家兔皮肤和滴药于眼结膜囊内。结果:驱蚊保护时间达6h以上;抑菌率达99.99%;小鼠急性经口LD50为1302.25mg/kg;对家兔皮肤刺激积分值为0,48h后对眼刺激平均指数为0.5。结论:本品对蚊虫有一定驱避保护作用,对霉菌生长有较强的抑制作用,而且毒性低,使用安全。
关键词: 樟脑油精, 驱避效果, 抑菌作用, 急性毒性
MA Zhen-hong; CHEN Shu-yu; QU Ming-fang. Laboratory Evaluation of Efficacy and Safety of Camphor Oil Spray[J]. Chines Journal of Vector Biology and Control.
马桢红;陈淑玉;瞿明芳. 樟脑油精药效及其安全性评价[J]. 中国媒介生物学及控制杂志.
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