ISSN 1003-8280 CN 10-1522/R 中国疾病预防控制中心 主办
Chines Journal of Vector Biology and Control
• muci • Previous Articles Next Articles
ZHANG Ji-bo; GUAN Yu-hui; XING Li; et al
Online:
Published:
张稷博;关玉辉;邢丽;王树诚
Abstract: Objective:Trial-produce slow relesase repellent with inclusion compound technology.Methods:The deet inclusion compound was made in method of saturated solution.Its toxicity was tested by using method of GB7919-87.Repelling effect of human body was tested by testing methed of GB/T17322.10-1998.Result:Its oral and dermal LD50were over5000mg/kgand3000mg/kg respectively in rats,efficacious time was 6.2±0.54 for human body,it has no dermal and eye irritancy on rabbits.Conclusion:The deet inclusion compound has almost no toxicity for human boday,it was very steady on light and heat,the active in gredient were slow relesase.
摘要: 目的:采用包结化合物制作技术,试制缓释驱避剂。方法:用饱和水溶液法制作避蚊胺包结化合物;按GB7919-87进行动物急性毒性试验;按GB/T17322.10-1998进行人体驱蚊试验。结果:避蚊胺包结化合物对大白鼠急性经口LD50>5000mg/kg,急性经皮LD50>3000mg/kg,对家兔的皮肤和眼睛无刺激;20%避蚊胺包结化合物对人体有效保护时间(6.2±0.45)h。结论:避蚊胺包结化合物无急性毒副作用,对光、热的稳定性增强,缓释作用明显。
关键词: β-CD, 避蚊胺, 白纹伊蚊, 毒性, 驱避效果
ZHANG Ji-bo; GUAN Yu-hui; XING Li; et al. Development and Biology Efficacy Appraisement of Deet Inclusion Compound[J]. Chines Journal of Vector Biology and Control.
张稷博;关玉辉;邢丽;王树诚. 避蚊胺包结化合物的研制及其生物效能评价[J]. 中国媒介生物学及控制杂志.
0 / / Recommend
Add to citation manager EndNote|Ris|BibTeX
URL: http://www.bmsw.net.cn/EN/
http://www.bmsw.net.cn/EN/Y2001/V12/I1/56