Abstract It was reported in the paper the results of Brodifacoum to control the two major rodents- Rattus norvegicus and Apodemus agrarius in the field. The Brodifacoum was produced by Siyang Raticide Factory. In the test, the control rate was above 96%, obviously higher than that of Bromadiolone. Dead rats appeared 3 days after Brodifacoum treated, and the dead rats killed by Brodifacoum was more than that of Bromadiolone. In the test area, no poisoned non-target animals to be founded.