Abstract: From October 1994 2 years' observation op the population innoculated with tyPe Ⅰinactivated vaccine (prepared from tissue culture of Mongolian gerbils kidney supplied by Institute of Biological Products, shanghai) showed that there was 1 case in the innoculated group, the morbidity rate was 9.27/100 000, 17 cases in the control group, the morbidity rate was 16.198/ 100 000 and the protection rate was 94.28%.The results indicated that the middle-term protection efficacy of the vaccine be sound.The case in the innoculated group was a patient of light-tyPe spoptom.Before epidemic peak (in October 1996) and after epidemic peak (in March 1997), 4 of the innoculated population had seroconversion of immunofluorescent antibody by IFA, but they had no clinical symptom.These showed that the vaccine didn't cause antibody dependent immunization enhancement.

摘要： 观察沙鼠肾细胞Ⅰ型灭活疫苗的中期流行病学效果。方法：采用间接免疫荧光抗体法（IFA）、微量细胞变性中和试验（MCPENT），分别检测荧光抗体及中和抗体；调查接种组与对照组人群发病情况。结果：自1994年10月以来的两年中，接种组发病1例（轻型），发病率为9．27／10万；对照组发病问例，发病率为161.98／10万，保护率为94．28％。流行高峰前（1996年10月）、后（1997年3月）新出现荧光抗体阳性4人，均无任何临床表现。结论：该疫苗有良好的中期防病效果；接种人群不存在免疫增强现象。

关键词: 肾综合征出血热, 灭活疫苗, 流行病学效果, 免疫增强