ISSN 1003-8280 CN 10-1522/R 中国疾病预防控制中心 主办
Chines Journal of Vector Biology and Control
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Tang Han-ying; Lu Qun-ying; Zhu Zhi-yong
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唐汉英; 陆群英; 朱智勇
Abstract: This paper describes that the inactivated HFRS vaccine (type I) cultured in M.unguiculatus kidney cell was used on human, the induced neutralization antibody were observed Persistently.The results showed that about 90% seroconversion rate of neutralization antibody occurred after primary injection three times.But the persistent time was shorter.It reduced 30% in a year after primary immunization.When the secondary immunizatiom (one injection) was done, the persistent time was longer.About 50% seroconversion rate of neutralization antibody occurred at six years after secondary immunization.There fore, this suggestes that the secondary immunization be necessary.
摘要: 目的:观察肾综合征出血热(HFRS)沙鼠肾灭活疫苗的免疫持久性。方法:采用空斑减少中和试验检测静脉血中和抗体。结果:初免3针后中和抗体阳转率达90%左右,但持续时间不长,一年后降至30%加强1针免疫后则持续时间较长,6年后仍为50%左右。结论:此疫苗近期免疫效果较好,加强免疫十分必要。
关键词: HFRS灭活疫苗, 中和抗体, 持久性
Tang Han-ying; Lu Qun-ying; Zhu Zhi-yong. Observation of Immune Persistence of Inactivated HFRS Vaccine Cultured in M.unguiculatus Kidney Cell[J]. Chines Journal of Vector Biology and Control.
唐汉英; 陆群英; 朱智勇. 肾综合征出血热沙鼠肾灭活疫苗的免疫持久性观察[J]. 中国媒介生物学及控制杂志.
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