ISSN 1003-8280 CN 10-1522/R 中国疾病预防控制中心 主办
Chines Journal of Vector Biology and Control
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Zhu Feng-cai;Wu Yang-sheng et al
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朱凤才1; 吴扬生1; 王庆奎2; 祁洪山3; 汪杰4; 金志宽1; 施平1; 胡静1; 祖荣强1; 刘光中1
Abstract: In 1994, 4871 volunteers were inoculated with the whole course(three injections)of the inactivated Meriones ungiculetus kidney cell vaccine(type Ⅰ vaccine)in Donghai county; 4571 and 6658 volunteers were inoculated with the whole course(three injections)of inactivated hamster kidney cell vaccine(type Ⅱ vaccine)in Ganyu county and Dongxin farm, respectively. The three areas were serious endemic of HFRS. The observation during one year period showed: the two kinds of the vaccine were of slight side effect, safety for the volunteers. The seroconversion rate of fluorescent antithey and neutralizing antibody were 84. 4% and 37. 0%,two weeks after the whole course of immunization in the type Ⅰ group. In the typeⅡgroup,the seroconversion rate of fluorescent antibody and neutralizing antibody were 48. 8% and 94. 6%, respectively, The protective rates of the type Ⅰ and type Ⅱ vaccine were 56.0%and 93.0%by one year,respectively.
摘要: 对东海、赣榆、灌云东辛农场3个HFRS高发地区分别进行4871人份Ⅰ型疫苗、4571人份Ⅱ型疫苗和6658人份Ⅲ型疫苗的人群接种,并进行了1年期观察。结果:该两型苗的副反应均较低,安全性好,Ⅰ型疫苗全程免后2周荧光抗体阳转率为84.4%,中和抗体阳转率为37.0%;Ⅱ型疫苗荧光抗体阳转率为48.8%,中和抗体阳转率为94.58%;Ⅰ型疫苗1年期内保护率为56.0%,Ⅱ型疫苗为93.0%。
关键词: 肾综合征出血热, 灭活疫苗, 血清学效果, 防病效果, 安全性
Zhu Feng-cai;Wu Yang-sheng et al. Preliminary Field Observation on the Mass with Inactivated Vaccine against Haemorrhagic Fever with Renal Syndrome in Jiangsu PrOvince[J]. Chines Journal of Vector Biology and Control.
朱凤才1; 吴扬生1; 王庆奎2; 祁洪山3; 汪杰4; 金志宽1; 施平1; 胡静1; 祖荣强1; 刘光中1. 江苏省肾综合征出血热灭活疫苗免疫效果现场考核初报[J]. 中国媒介生物学及控制杂志.
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