Tick salivary gland anti-hemostatic molecules and research progress

doi:10.11853/j.issn.1003.8280.2017.04.026

Abstract

Abstract: Ticks are obligatory blood feeding ectoparasites, they can transmit various pathogens causing severe damages to human health and animal husbandry. Tick salivary gland can secrete various anti-hemostatic compounds, which play important roles in feeding on host and pathogen transmission. The anti-hemostatic compounds derived from salivary glands of ticks can be divided into three types:platelet aggregation inhibitors, vasodilators and anticoagulants. Here, we reviewed research progress on the anti-hemostatic compounds of ticks, in hope of providing basic knowledge for further exploring the tick-host interaction and promoting pharmacological studies on these compounds.

Key words: Tick, Salivary gland, Anti-hemostatic, Functional molecules

摘要： 蜱为专性吸血的体外寄生虫，可传播多种病原体，严重威胁人类健康和畜牧业发展。蜱唾液腺分泌多种抗止血分子，在蜱类吸血及传播病原体的过程中发挥重要作用。蜱唾液腺分泌的抗止血分子可分为抗血小板聚集分子、血管扩张分子和抗凝血分子3类。通过对蜱类唾液腺抗止血分子及其研究进展进行综述，为深入研究蜱类与宿主的相互作用关系及功能分子药物开发奠定基础。

关键词: 蜱, 唾液腺, 抗止血, 功能分子

CLC Number:

R384.4

YANG Xiao-hong, MENG Hao, QI Li-li, LIU Jing-ze. Tick salivary gland anti-hemostatic molecules and research progress[J]. Chines Journal of Vector Biology and Control, 2017, 28(4): 400-404.

杨晓红, 孟浩, 齐莉莉, 刘敬泽. 蜱唾液腺抗止血分子及研究进展[J]. 中国媒介生物学及控制杂志, 2017, 28(4): 400-404.

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