Abstract:

Objective To explore the main risk factors related to the incidence of Japanese encephalitis (JE), and to provide evidence for the prevention and control of JE.Methods We collected the data about case information by searching PubMed, China National Knowledge Infrastructure (CNKI), China Biology Medicine Disc (CBM), Wanfang Database, and database for Chinese Technical Periodicals (VIP) from 1995 to 2015, and we applied Stata 12.0 software for the Meta-analysis. Results Totally 7 case-control studies were selected (including 412 cases and 763 controls).The results of Meta-analysis showed that the factors of raising swines, house location, immunization history, and using screen windows were influential factors, and the OR value (95%CI) were 2.87(2.01-4.10), 2.46(1.55-3.89), 0.12(0.04-0.37), and 0.37(0.17-0.83), respectively. Conclusion Raising swines and living in the peripheral villages were risk factors of JE, and JE vaccination and using screen windows were protective factors.

Key words: Japanese encephalitis, Risk factors, Meta-analysis

摘要：

目的 探讨流行性乙型脑炎（乙脑）发病的危险因素，为其预防决策提供依据。方法 通过检索PubMed、中国期刊全文数据库、中国生物医学文献数据库、万方数据知识服务平台和维普数据库等，收集1995－2015年发表的关于乙脑发病危险因素的病例对照研究资料，采用Stata 12.0软件进行Meta分析。结果 共纳入文献7篇，病例412例，对照763例。养猪、房屋位置、免疫史、使用纱窗是乙脑发病的影响因素，各影响因素的合并效应比值比及其95%可信区间分别为2.87（2.01~4.10）、2.46（1.55~3.89）、0.12（0.04~0.37）和0.37（0.17~0.83）。结论 养猪、居住在村外围是乙脑发病的危险因素，接种疫苗、使用纱窗是乙脑发病的保护性因素。

关键词: 流行性乙型脑炎, 危险因素, Meta分析