Chines Journal of Vector Biology and Control ›› 2013, Vol. 24 ›› Issue (4): 367-369.DOI: 10.11853/j.issn.1003.4692.2013.04.029

• Review • Previous Articles     Next Articles

Research advances in key genes in prophenoloxidase-activating system of Musca domestica

LI Dian-xiang1, ZHEN Tian-min2, XIN Zheng3, WANG Li-juan1, MA Shu-fang1, GUO Wen-zong1, LIU Zheng-ming1   

  1. 1 School of Medicine and Life Science,University of Jinan, Jinan 250022, Shandong Province, China;
    2 Shandong Academy of Medical Sciences;
    3 Jinan Center for Disease Control and Prevention, Jinan 250021, Shandong Province, China
  • Received:2013-03-08 Online:2013-08-20 Published:2013-08-20
  • Supported by:

    Supported by the Natural Science Foundation of Shandong Province(No. ZR2011CM012)and the Scientific and Technological Developing Project of Shandong Province(No. 2012GGB01172)

家蝇酚氧化酶原系统关键基因的研究进展

李殿香1, 甄天民2, 辛正3, 王丽娟1, 马淑芳1, 郭文宗1, 刘政明1   

  1. 1 济南大学医学与生命科学学院, 山东 济南 250022;
    2 山东省医学科学院;
    3 济南市疾病预防控制中心, 山东 济南 250021
  • 通讯作者: 辛正,Email: xinzheng121@163.com
  • 作者简介:李殿香(1963- ),女,博士,主要从事动物生化与分子生物学研究。Email: dianxiangli@126.com
  • 基金资助:

    山东省自然科学基金(ZR2011CM012);山东省科技发展计划项目(2012GGB01172)

Abstract:

Prophenoloxidase-activating system is an important part in the immune system of Musca domestica and plays an essential role in the pathogen recognition and immune defense. Until now, however, the key genes in the prophenoloxidase-activating system and the system's action mechanism remain unclear. On this occasion, we performed transcriptomic analysis of M. domestica to obtain a number of expressed sequence tags of the key genes of prophenoloxidases, prophenoloxidase-activating enzymes, serine proteinase inhibitors (Serpin), and upstream pattern-recognition receptors in the prophenoloxidase-activating system. This article reviews the research advances in the key genes in the prophenoloxidase-activating system of M. domestica.

Key words: Musca domestica, Prophenoloxidase-activating system, Pattern-recognition receptor, Prophenoloxidase-activating enzyme, Serine proteinase inhibitor

摘要:

家蝇酚氧化酶原系统是家蝇免疫体系重要的组成部分,在对病原识别和免疫防御中发挥着强有力的作用。目前,对该系统的关键基因和作用机制还不清楚。为此,进行了家蝇转录组分析,得到参与酚氧化酶原系统的酚氧化酶原、酚氧化酶原激活酶、Serpin型丝氨酸蛋白酶抑制因子及上游的模式识别受体等关键基因的EST(基因表达序列标签),现就它们的研究进展予以综述。

关键词: 家蝇, 酚氧化酶原系统, 模式识别受体, 酚氧化酶原激活酶, 丝氨酸蛋白酶抑制剂

CLC Number: