Objective To design and build sanitation infrastructure in rural areas and to effectively control vector breeding. Methods The sanitation infrastructure, suitable for vector management of mosquito, rodent, fly, cockroach, and offensive odor in rural areas, was designed and built to control vectors in rural areas and improve the quality of living environment for farmers. Results The field monitoring of 2198 villages and 20 towns in Guangdong province, China, where the sanitation infrastructure was built, showed that the population densities of mosquitoes, commensal rodent, flies, and cockroaches decreased by more than 90%, and over 95% of the residents were satisfied with the sanitary environment. Conclusion In rural areas, the construction of sanitation infrastructure for vector management has the advantages of low investment and quick and good effect and is welcome to residents. It is suitable for widespread use in developing rural areas.