中国媒介生物学及控制杂志

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拟除虫菊酯浸泡蚊帐对嗜人按蚊毒杀作用的实验室评价

潘波1,2;陈晓光1;朱泰华2;吴旭光2;吴军2   

  1. 南方医科大学公共卫生与热带医学学院;广东省疾病预防控制中心;广东省疾病预防控制中心 广州
  • 出版日期:2006-10-20 发布日期:2006-10-20

Laboratory Evaluation on the Toxic Effects of Bednets Impregnaed with Permethrin and Cyhalothrin and Cyfluthrin against Anopheles anthropophagus

PAN Bo; CHEN Xiao-guang; ZHU Tai-hua; WU Xu-guang; WU Jun   

  1. Southern Medical University, Guangzhou 510515, China
  • Online:2006-10-20 Published:2006-10-20

摘要: 目的 实验室评价拟除虫菊酯浸泡蚊帐对嗜人按蚊的毒杀作用。方法 棉纱蚊帐浸泡拟除虫菊酯药液后,按照WHO的实验室生物测试方法,每月对嗜人按蚊进行实验室生物持效测试和KT50及LT50生物测试。结果 二氯苯醚菊酯250和500 mg a.i/m2浸帐对嗜人按蚊的持效分别可达10和13个月,毒杀平均死亡率分别为73.7%和77.0%;500 mg a.i/m2二氯苯醚菊酯浸帐后180~305 d测试,对嗜人按蚊的KT50平均为16.9 min;LT50平均为22.1 min。KT50与LT50的比值为1∶1.3。氯氟氰菊酯20 mg a.i/m2浸泡蚊帐后1年内对嗜人按蚊的毒杀平均死亡率为79.8%,在10 mg a.i/m2剂量下,毒杀平均死亡率为73.5%。氟氯氰菊酯40 mg a.i/m2浸泡蚊帐后8个月内对嗜人按蚊的毒杀平均死亡率为78.1%;在20 mg a.i/m2剂量下,浸帐后6个月内对嗜人按蚊的毒杀平均死亡率为73.2%。结论 500 mg a.i/m2二氯苯醚菊酯2、0 mg a.i/m2氯氟氰菊酯、40 mg a.i/m2氟氯氰菊酯浸泡蚊帐对嗜人按蚊均有较好的持效和毒杀作用。

关键词: 嗜人按蚊, 拟除虫菊酯, 浸泡蚊帐, 死亡率

Abstract: Objective To evaluate the toxic effects of bednets impregnated with pyrethroid for Anopheles anthropophagus in laboratory.Methods During the tests of mortality the plastic funnels were provided by WHO for bioassay and KT50,LT50.Results In laboratory,bednets impregnated with(250 mg a.i/m2 and(500 mg a.i/m2 permethrin caused 73.7% mean mortalities within 10 months and 77.0% within 13 months respectively on laboratory-bred (An.anthropophagus).The KT50 forAn.anthropophagus was 16.2-18.7 min averagely(16.9 min) as determined 180-305 days after the permethrin-impregnated bednets at the dose of 500 mg a.i/m2 while the LT50 was 18.1-26.7 min averagely 22.1 min.The ratio of KT50 to LT50 was(1∶1.3).Bednets impregnated with 20 mg a.i/m2 and 10 mg a.i/m2 cyhalothrin caused average mortalities of 79.80 and 73.5% within one year on An.anthropophagus respectively.And bednets impregnated with 40 mg a.i/m2 and 20 mg a.i/m cyfluthrin caused average mortalities of 78.1% within 8 months and 73.2% within 6 months onAn.anthropophagus respectively.Conclusion It showed that bednets impregnated with 500 mg a.i/m2 permethrin,20 mg a.i/m2 cyhalothrin and(40 mg a.i/m2 cyfluthrin have longer residual effect and stronger killing effect.Can effectively controlAn.sinensisand malaria in China.