关键词: 钩端螺旋体病, 菌群(型)更迭, 宿主

Abstract: Objective The purpose was to study the serogroup(serovar) alternation of Leptospira interrogans in Wannan mountain areas of Anhui province.Understanding the distribution of serogroups(serovars) was greatly helpful in the prevention of leptospirosis.Methods The specimens from patients and animals were used for bacteria isolation and the sera from cases,suspicious cases and natural populations were used for antibody detection by method of microscopic agglutination test(MAT).Results The predominant antibody of serogroup was Sejroe with positive rates of 34.13% and 25.82% in patients and natural populations respectively in these areas.Conclusion The results showed that the dominant serovar of Leptospira interrogans had been alternated in recent years compared with that in 1990s.Leptospira interrogans serovar medanensis was firstly isolated from Apodemus agrarius in this area.The rodents were still approved the cardinal reservoirs,however,buffalo was considered as one of the host animal of pathogenic Leptospires.